Recovery Lasers in Medical Science · 2015
Effect of phototherapy (LLLT and LED) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis
Finding: Across pooled randomized trials, red/near-infrared phototherapy applied around exercise improved muscle performance and reduced markers of muscle fatigue and damage compared with placebo.
Recovery Journal of Biophotonics · 2016
Photobiomodulation in human muscle tissue: an advantage in sports performance?
Finding: This review concluded that red/near-infrared light delivered before or after exercise can enhance muscular performance and recovery and reduce muscle inflammation and oxidative stress, while noting that optimal dosing still needs standardization.
review of 46 clinical trials (~1,045 participants) View study → Skin Photomedicine and Laser Surgery · 2014
A controlled trial of red and near-infrared light for fine lines, wrinkles, skin roughness, and intradermal collagen density
Finding: Treated participants showed significantly improved skin complexion and feeling, reduced wrinkles and roughness, and an ultrasound-confirmed increase in intradermal collagen density versus untreated controls.
Skin Seminars in Cutaneous Medicine and Surgery · 2013
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
Finding: This review describes how red and near-infrared light absorbed by mitochondrial chromophores in skin cells can stimulate healing, reduce inflammation, and improve outcomes in conditions such as photoaging, acne, and wound healing.
Sleep Journal of Athletic Training · 2012
Red light and the sleep quality and endurance performance of Chinese female basketball players
Finding: Fourteen nights of whole-body red-light irradiation significantly improved subjective sleep quality (PSQI), raised serum melatonin, and improved endurance performance versus placebo, with sleep and melatonin changes correlated.
n = 20 elite athletes (10 red light, 10 placebo) View study → Sleep Journal of Clinical Sleep Medicine · 2023
A randomized, sham-controlled trial of a novel near-infrared phototherapy device on sleep and daytime function
Finding: Adults using a near-infrared light collar before bed reported improved sleep quality, relaxation, and mood versus sham, although objective actigraphy sleep measures did not differ between groups.
Pain The Lancet · 2009
Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
Finding: This Lancet meta-analysis found that low-level laser therapy reduced pain immediately after treatment in acute neck pain and for up to 22 weeks after treatment in chronic neck pain.
Pain BMJ Open · 2019
Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials
Finding: Pooled randomized trials showed that low-level laser therapy reduced pain and disability in knee osteoarthritis, with larger and longer-lasting effects when WALT-recommended dosages were used and no adverse events reported.
Pain AIMS Biophysics · 2017
Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
Finding: This mechanistic review explains how red and near-infrared light produces a pronounced anti-inflammatory effect, supporting its use for inflammatory and painful conditions affecting joints and soft tissue.
Hair Lasers in Surgery and Medicine · 2013
The growth of human scalp hair mediated by visible red light laser and LED sources in males
Finding: In this double-blind sham-controlled trial, 655 nm red light applied to the scalp produced a significant ~39% increase in hair counts in men with androgenetic alopecia versus sham treatment.
Hair American Journal of Clinical Dermatology · 2014
Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, double-blind study
Finding: Across four sham-controlled trials, a low-level laser device produced statistically significant increases in terminal hair density versus sham in both men and women with pattern hair loss.
Cognitive Neuroscience · 2013
Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans
Finding: In this placebo-controlled study, a single transcranial near-infrared laser treatment to the forehead improved sustained attention and short-term memory and enhanced positive mood relative to placebo.
Cognitive Molecular Neurobiology · 2018
Brain photobiomodulation therapy: a narrative review
Finding: This review summarizes how transcranial red/near-infrared light may enhance neuronal metabolism and anti-inflammatory, antioxidant, and neurogenic responses, with early evidence across cognitive, mood, and neurodegenerative conditions.
Cognitive Photobiomodulation, Photomedicine, and Laser Surgery · 2019
Effects of home photobiomodulation treatments on cognitive and behavioral function, cerebral perfusion, and resting-state functional connectivity in patients with dementia: a pilot trial
Finding: In this small pilot trial, home transcranial 810 nm photobiomodulation was associated with improved cognitive and behavioral scores and increased cerebral perfusion and connectivity, though the tiny sample means results are preliminary.
Safety Aesthetic Surgery Journal · 2023
Photobiomodulation: a systematic review of the oncologic safety of low-level light therapy for aesthetic skin rejuvenation
Finding: This systematic review found no clinical evidence linking photobiomodulation to development or recurrence of malignancy, concluding it is oncologically safe for aesthetic skin use, including in patients with a cancer history.
Safety Cancer Medicine · 2020
Safety and efficacy of photobiomodulation therapy in oncology: a systematic review
Finding: This WALT systematic review concluded that, at recommended clinical parameters, photobiomodulation therapy is safe with respect to tumor growth and is supported for managing certain cancer-treatment side effects.
No studies in this category yet — more are being added.